We provide rigorously conducted literature reviews to address a variety of research questions. Systematic literature reviews are conducted and reported in accordance with recommended guidelines (Cochrane Collaboration, PRISMA). We conduct systematic literature reviews to inform quantitative meta-analysis and network meta-analysis, as well as more descriptive reviews aimed at broadly characterizing the scientific literature with respect to a variety of research questions. In addition to formal systematic literature reviews, we also provide targeted literature reviews where a more efficient strategy best meets a client’s needs.
Following a systematic literature review, we perform rigorously designed and conducted quantitative evidence syntheses, including standard meta-analysis and network meta-analysis. We analyze complex networks, including single-arm trials, observational studies, or the incorporation of individual patient data for a subset of comparators.